What is NAD+, and why do people use it?

NAD+ is a coenzyme found in every cell. It helps your body produce energy, support metabolism, and carry out DNA repair. NAD+ levels naturally decline with age, which is why some people use NAD+ supplements as part of a wellness routine.

What do NAD+ supplements support?

People use NAD+ supplements to support cellular energy, cognitive function, metabolism, and healthy ageing. Results vary, and research is ongoing.

How can you verify that your My NAD product is genuine?

Each genuine My NAD product includes a unique authenticity verification system. You can verify your product through the official authenticity portal to confirm it is genuine.

Why is product authentication important for supplements?

Counterfeit supplements may contain incorrect ingredients, improper dosages, or poor-quality materials. Verifying authenticity helps ensure you receive a genuine product that meets quality and safety standards.

Who should consider taking NAD+ supplements?

Adults interested in supporting healthy aging, energy metabolism, cellular health, and overall wellness may consider NAD+ supplements. Always consult a healthcare professional before starting any new supplement.

Are NAD+ supplements generally well tolerated?

NAD+ supplements are generally well tolerated when you use them as directed. If you are pregnant, breastfeeding, taking medication, or managing a medical condition, you should speak with a healthcare professional before use.

Why do NAD+ levels decline with age?

Research indicates that NAD+ levels naturally decrease as we age due to changes in cellular metabolism and increased demand for DNA repair processes. This decline has led to growing interest in NAD+ supplementation.

How may My NAD products fit into a healthy aging routine?

NAD+ supports cellular energy production and DNA repair. You may use My NAD products as part of a broader routine that includes good nutrition, exercise, sleep, and regular medical guidance. Results vary from person to person.

Where can I buy genuine My NAD products in the UK?

To ensure authenticity and quality, purchase My NAD products only through the official My NAD website or authorized distributors.

NAD+ and GLP-1 Weight-Loss Injections: What to Know Before Combining Them

NAD+ Blogs

Oct 4

4 min read

There's no evidence of a direct interaction between NAD+ and GLP-1 weight-loss injections such as semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro) — but the question is more nuanced than a simple yes or no. Because NAD+ self-injection kits are delivered under the skin rather than swallowed, they sidestep the slowed digestion that GLP-1 medicines are known to cause, which matters far more for oral NAD+ precursor supplements. Before combining any supplement with a prescription weight-loss injection, the sensible first step is always a conversation with the prescriber who put you on it.

How GLP-1 Weight-Loss Injections Change Digestion

Semaglutide and tirzepatide belong to a class of medicines called GLP-1 receptor agonists, originally developed for type 2 diabetes and now widely prescribed for weight management under brand names including Wegovy, Ozempic, Mounjaro and Saxenda. They work partly by slowing gastric emptying — the rate at which food, and anything else, leaves the stomach — which is one reason appetite drops. The NHS Specialist Pharmacy Service notes that GLP-1 receptor agonists delay gastric emptying and have the potential to alter the rate of absorption of concomitantly administered oral medicines, although it adds that most manufacturer studies haven't found this to be clinically significant for routine oral medicines. This single mechanism is the main reason NAD+ and GLP-1 weight-loss injections come up in the same conversation at all.

Does NAD+ Interact With GLP-1 Receptor Agonists Like Ozempic, Wegovy or Mounjaro?

No published research has specifically tested NAD+ alongside semaglutide, tirzepatide or liraglutide, so any answer here is reasoned from how each is absorbed rather than from a head-to-head trial. A self-administered NAD+ injection is delivered subcutaneously, bypassing the stomach and intestines entirely — the slowed gastric emptying that GLP-1 medicines cause has little relevance to something that never passes through the gut. The picture is different for oral NAD+ precursors such as NMN or NR tablets, which are swallowed and absorbed the same way as other oral supplements, and could plausibly be affected by slower digestion the way other oral medicines sometimes are.

Diagram comparing how an oral NAD+ precursor supplement and a NAD+ self-injection are absorbed differently when taking a GLP-1 weight-loss medication — Oral NAD+ precursors pass through the gut; NAD+ injections bypass it entirely.

Side Effects That Can Overlap

Some side effects of NAD+ injections and GLP-1 medicines can look similar, which may make it harder to tell which one is responsible if symptoms appear. GLP-1 receptor agonists commonly cause gastrointestinal effects — the MHRA has warned that gastrointestinal side effects can persist for several days and may affect more than 1 in 10 patients, and in some cases lead to dehydration severe enough to need hospital treatment. NAD+ injections, meanwhile, are associated with mild nausea, flushing, fatigue or injection-site irritation in some users, particularly when a dose is increased too quickly. If you're combining the two, it can genuinely be difficult to know which treatment is behind a symptom — another reason to flag both to whoever oversees your GLP-1 prescription.

What to Tell Your Prescriber Before Combining Them

NAD+ self-injection kits are not licensed by the MHRA as a medicine, and GLP-1 weight-loss injections are prescription-only medicines with their own monitoring requirements. If you're using or considering both, it's worth reading our guide on who should avoid NAD+ injections and being upfront with your GP, pharmacist or weight-management clinician about:

That you're using, or planning to use, an unlicensed injectable NAD+ supplement alongside your prescribed medication
Any digestive symptoms you're experiencing, so they can work out which treatment is the likely cause
The dose and frequency of your NAD+ injections, in case your prescriber wants to space things out
Any other supplements, including NMN, NR or vitamin B3, that you're taking orally alongside both

Your prescriber can only account for what they know you're taking — leaving out an unlicensed supplement doesn't protect you, it simply removes one piece of the picture.

Frequently Asked Questions

Can I inject NAD+ on the same day as my GLP-1 weight-loss injection?

There's no specific research saying this shouldn't be done, but spacing the two out and telling your prescriber you're doing it is the more cautious approach, especially while you're still monitoring how your body responds to the GLP-1 medicine.

Will NAD+ make Ozempic, Wegovy or Mounjaro less effective?

There's no evidence that NAD+ reduces how well a GLP-1 medicine works. The two act through entirely different pathways in the body, and no interaction study has found otherwise — though the absence of a dedicated study is a reason for caution rather than reassurance.

Should I choose NAD+ injections or oral NAD+ precursor tablets if I'm on a GLP-1 medicine?

If avoiding any theoretical absorption issue from slowed digestion matters to you, an injection sidesteps the gut entirely, whereas an oral NMN or NR tablet is absorbed the same way as other swallowed supplements. Neither option has been studied specifically alongside GLP-1 medicines, so this is a practical consideration rather than a proven safety difference.

Could nausea from my GLP-1 injection be mistaken for a reaction to NAD+?

Yes, potentially. Nausea is one of the most commonly reported effects of GLP-1 receptor agonists and is also sometimes reported with NAD+ injections, so it can be hard to tell which one is responsible. Keeping a simple note of timing and symptoms can help your prescriber work out what's going on.

Is it safe to start NAD+ injections while I'm still adjusting to a new GLP-1 dose?

Starting two new things at once makes it harder to identify the source of any side effect, so many clinicians would suggest waiting until your GLP-1 dose is stable before introducing anything new, including NAD+. This is a general caution rather than a specific rule, so check with your prescriber for guidance tailored to you.

This article is for general informational purposes only and does not constitute medical advice. Always speak with a qualified healthcare professional before starting any new supplement or injectable therapy.